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DBT-Bioinformatics Facility
The Bioinformatics Infrastructure Facility (BIF) at Maharani Lakshmi Ammanni College for Women (mLAC) was established in 2007 with support from the Department of Biotechnology (DBT), Govt. of India. The facility is dedicated to promoting bioinformatics teaching and research at the undergraduate and postgraduate levels.
Centre Information
Name of the Centre
Maharani Lakshmi Ammanni College For Women, Autonomous (mLAC)
Year of Establishment
2007
Area of Specialization
Genomics, Database Creation and Drug Discovery
Dr. Sushil Kumar Middha
Coordinator
Associate Professor, Department of Biotechnology
mLAC, 18th Cross, Malleswaram, Bangalore
Dr. Usha T
Co-Coordinator
Associate Professor, Dept. of Biochemistry
mLAC, 18th Cross, Malleswaram, Bangalore
Manpower Details
| Sl. No | Designation | Name |
|---|---|---|
| 1 | Research Associate | Dr. Jolitha.A.B |
| 2 | Technical Assistant | Ms. Preethi |
| 3 | Studentship | Ms. Shaliat Santham |
| 4 | Studentship | Ms. Chandini.M |
| 5 | Studentship | Ms. Suchismita Dey |
Summary of Progress (2017-18)
- Research publications in peer reviewed journals
- Poster/paper presentation in National and International conferences
- One training workshop and one National conference
- Training programs for students: BIF has conducted workshops for 12th standard, UG and PG students to create awareness about bioinformatics and its wide use in making biology learning more interesting and exciting.
- Specialized training programs: For Biotechnology Finishing School students (Govt. of Karnataka initiative supported by ABLE) for internship and placement in the biotechnology industry.
Area of Research
Genomics, Database development and Drug discovery
BIF Portal
www.bicmlacw.org
Current Projects
- Database for metabolic pathways of secondary metabolites with anticancer properties
- In Silico Docking to elucidate the effect of Plant-Originated Inhibitors and L1 capsid Protein of Highly Threatening Human Papillomavirus
- Genome sequence analysis of Punica granatum to identify key genes in secondary metabolite production
- Comparative genome analysis of Cajanus cajan and Brassica juncea species for anticancer activity
- Pharmacophore Modeling and Virtual Screening for Acetylcholinesterase Inhibitors
- Analysing antidiabetic, anticancer and anti-inflammatory activity of natural compounds in Myrica nagi and M. esculenta
- Phylogenetic analysis of various species of bamboo
Research Publications
| Sl. No | Title of the Paper | Authors | Journal | IF |
|---|---|---|---|---|
| 1 | Identification of bioactive glucose lowering compounds of Hodgsonia heteroclita fruit pulp. | T Usha, Goyal AK, D Narzary, et al. | Bioengineered | 2.3 |
| 2 | Anti-diabetic potential of S. foetida seed and its peel: In-silico study. | Sengupta S, Usha T, Middha SK, et al. | Computational Biology | 1.5 |
Future Activities Proposed
- Transcriptome analysis of Centella asiatica to understand the anxiolytic effect
- 3D QSAR pharmacophore mapping of natural compounds for cervical cancer
- Training program on commercial software (Discovery studio) and R programming
- Training program on NGS and data analysis
- Conducting national-level conferences and workshops on drug Discovery and NGS
- Free training to Pre-university students to create interest towards life sciences
- Diploma and Certificate courses in Bioinformatics for UG and PG students
- Creating human resource for industry internship programs
Infrastructure & Facilities
Hardware
- 25 Computers (8/16GB RAM)
- Dedicated BSNL Lease Line
- High-end Xeon Server
- High-end Workstation (32GB RAM)
Software Packages
Commercial:
- Discovery Studio 3.5 Suite, Accelrys GCG
- CLC BIO Suite (for NGS)
Free Wares:
- Hex, RasMol, Qmol, Autodock
- FastQC, SPAdes, SSPACE, MaSuRCA